Abstract
The essential oil of leaves and flowers of Clinopodium nubigenum (Kunth.) Kuntze (Lamiaceae) collected in the province of Pichincha-Ecuador was steam distilled and analyzed by gas chromatography mass spectrometry (GC/MS) to determine its chemical composition. The majority of the compounds identified were carvacrol acetate (42.1%), carvacrol (20.6%), pulegone (6.3%) and thymol (5.5%). Antioxidant activity was assessed by the assays of diphenylpicrylhydrazyl (DPPH) (IC50: 1.8 μl / ml), 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) (IC50: 0.3 μl / ml) and β-carotene (IC50: 0.031 μl / ml) compared to Thymus vulgaris and butylated hydroxyanisole (BHA) as referents. The specie also shows a promising medicinal potential exhibiting significant antibacterial activity at different concentrations against Staphylococcus aureus (2.5% v/v), Streptococcus pyogenes (0.6% v/v), Streptococcus pneumoniae (0.6% v/v) and Streptococcus mutans (0.6% v/v), suggesting an interesting natural alternative in the fight against bacteria that generate resistance to other antibiotics.
Translated title of the contribution | Aceite esencial de Clinopodium Nubigenum (KUNTH) Kuntze: composición química, actividad antioxidante y prueba antimicrobiana contra patógenos respiratorios |
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Original language | English (US) |
Pages (from-to) | 149-157 |
Number of pages | 9 |
Journal | Pharmacognosy and Phytotherapy |
Volume | 10 |
Issue number | 10 |
DOIs | |
State | Published - 30 Sep 2018 |
Keywords
- 2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (abts)
- Antimicrobial test
- Clinopodium nubigenum
- Diphenylpicrylhydrazyl (dpph)
- Gas chromatography mass spectrometry (gc/ms)
CACES Knowledge Areas
- 215A Biochemistry