Mass Spectrometry and its Importance for the Analysis and Discovery of Active Molecules in Natural Products

Paco Fernando Noriega Rivera; Gabriela Estefania Gortaire Oleas; Edison Antonio Osorio Muñoz

Mass Spectrometry and its Importance for the Analysis and Discovery of Active Molecules in Natural Products

Título traducido de la contribución: Espectrometría de Masas y su Importancia para el Análisis y Descubrimiento de Moléculas Activas en Productos Naturales

Paco Fernando Noriega Rivera, Gabriela Estefania Gortaire Oleas, Edison Antonio Osorio Muñoz

Producción científica: Capítulo del libro/informe/acta de congreso › Capítulo

Resumen

La espectrometría de masas es una de las mejores técnicas para analizar la estructura de una molécula. Por lo general, proporciona información sobre el peso molecular de una sustancia y puede presentar unidades de masa atómica y hasta diez milésimas de unidades de masa atómica, según la precisión del analizador de masas. Además, proporciona información sobre los iones positivos formados en el proceso de ionización, lo que está ligado a la estructura química de la molécula y la naturaleza de los enlaces. Esta técnica es ampliamente utilizada para analizar compuestos de productos naturales. El desarrollo de la técnica combinado con el uso de software y bases de datos ha sido notable en los últimos años, mejorando los procesos de ionización y el análisis de iones. Dado que los productos naturales constituyen generalmente una mezcla de una cantidad compleja de componentes, se han desarrollado mecanismos de acoplamiento a técnicas cromatográficas de diversa índole. Esta revisión pretende mostrar cómo la espectrometría de masas ha contribuido al control de calidad cualitativo en productos naturales, así como en el hallazgo de nuevos metabolitos de interés industrial.

Título traducido de la contribución	Espectrometría de Masas y su Importancia para el Análisis y Descubrimiento de Moléculas Activas en Productos Naturales
Idioma original	Inglés estadounidense
Título de la publicación alojada	Natural Drugs from Plants
Editorial	IntechOpen
Número de páginas	12
ISBN (versión impresa)	978-1-80356-021-2
Estado	Publicada - 11 may. 2022

Palabras clave

Gc/ms
Hplc/ms
Mass spectrometry
Natural products
New metabolites

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abstract = "Mass spectrometry is one of the best techniques for analyzing the structure of a molecule. It usually provides information about the molecular weight of a substance, and it can present atomic mass units and up to ten thousandths of atomic mass units depending on the accuracy of the mass analyzer. In addition, it provides information on the positive ions formed in the ionization process, which is linked to the chemical structure of the molecule and the nature of the bonds. This technique is widely used for analyzing compounds from natural products. The development of the technique combined with the use of software and databases has been remarkable in recent years, improving the ionization processes and the ion analysis. Since natural products generally constitute a mixture of a complex quantity of components, mechanisms have been developed for coupling to chromatographic techniques of various kinds. This review aims to show how mass spectrometry has contributed to the qualitative quality control in natural products, as well as in the finding of new metabolites of industrial interest.",

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AU - Noriega Rivera, Paco Fernando

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N2 - Mass spectrometry is one of the best techniques for analyzing the structure of a molecule. It usually provides information about the molecular weight of a substance, and it can present atomic mass units and up to ten thousandths of atomic mass units depending on the accuracy of the mass analyzer. In addition, it provides information on the positive ions formed in the ionization process, which is linked to the chemical structure of the molecule and the nature of the bonds. This technique is widely used for analyzing compounds from natural products. The development of the technique combined with the use of software and databases has been remarkable in recent years, improving the ionization processes and the ion analysis. Since natural products generally constitute a mixture of a complex quantity of components, mechanisms have been developed for coupling to chromatographic techniques of various kinds. This review aims to show how mass spectrometry has contributed to the qualitative quality control in natural products, as well as in the finding of new metabolites of industrial interest.

AB - Mass spectrometry is one of the best techniques for analyzing the structure of a molecule. It usually provides information about the molecular weight of a substance, and it can present atomic mass units and up to ten thousandths of atomic mass units depending on the accuracy of the mass analyzer. In addition, it provides information on the positive ions formed in the ionization process, which is linked to the chemical structure of the molecule and the nature of the bonds. This technique is widely used for analyzing compounds from natural products. The development of the technique combined with the use of software and databases has been remarkable in recent years, improving the ionization processes and the ion analysis. Since natural products generally constitute a mixture of a complex quantity of components, mechanisms have been developed for coupling to chromatographic techniques of various kinds. This review aims to show how mass spectrometry has contributed to the qualitative quality control in natural products, as well as in the finding of new metabolites of industrial interest.

KW - Gc/ms

KW - Hplc/ms

KW - Mass spectrometry

KW - Natural products

KW - New metabolites

KW - Gc/ms

KW - Hplc/ms

KW - Mass spectrometry

KW - Natural products

KW - New metabolites

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M3 - Chapter

SN - 978-1-80356-021-2

BT - Natural Drugs from Plants

PB - IntechOpen

ER -

Mass Spectrometry and its Importance for the Analysis and Discovery of Active Molecules in Natural Products

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