Resumen
Cardiovascular remodeling induced by intrauterine growth restriction manifests in adulthood by more globular ventricles, as evidenced by in vivo measurements. The angle between the dominant vectors of the QRS and T-wave loops has been reported to be significantly altered as a result of the induced remodeling. To investigate whether the more globular ventricular shape was a major factor contributing to such alteration, we performed electrophysiological simulations in a human biventricular model for control and in a model obtained by deforming the control one to represent a more spherical left ventricle (SLV). Transmural ventricular heterogeneities and a Purkinje network were included. 12-lead ECGs were calculated, from which spatial QRS and T-wave angles were computed. The angle between the T-wave and the XZ-plane was found to increase in the SLV model, showing a variation similar to that reported in in vivo studies. However, the angle between the dominant vectors of the QRS and T-wave loops projected onto the XY-plane was lower for control, contrary to clinical observations in IUGR adults. Other clinical results could not be reproduced in our simulations either. Our findings suggest that a more globular left ventricular shape leads to changes in the angles of QRS and T-wave loops, but further research is needed to fully understand these changes and the underlying mechanisms.
Idioma original | Inglés |
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Título de la publicación alojada | 2020 Computing in Cardiology, CinC 2020 |
Editorial | IEEE Computer Society |
ISBN (versión digital) | 9781728173825 |
DOI | |
Estado | Publicada - 13 sep. 2020 |
Evento | 2020 Computing in Cardiology, CinC 2020 - Rimini, Italia Duración: 13 sep. 2020 → 16 sep. 2020 |
Serie de la publicación
Nombre | Computing in Cardiology |
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Volumen | 2020-September |
ISSN (versión impresa) | 2325-8861 |
ISSN (versión digital) | 2325-887X |
Conferencia
Conferencia | 2020 Computing in Cardiology, CinC 2020 |
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País/Territorio | Italia |
Ciudad | Rimini |
Período | 13/09/20 → 16/09/20 |
Nota bibliográfica
Publisher Copyright:© 2020 Creative Commons; the authors hold their copyright.