Biotransformation of Hyodeoxycholic and Deoxycholic Bile Acids

María Elena Maldonado Rodríguez, Mishell Enith Araujo Guayasamín, Andrea Alejandra Ruíz Moreno, Stefania Costa

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Resumen

Biotransformations involve the use of microorganisms that allow to modify organic compounds by generating different molecules with possible pharmacological, nutritional, or cosmetic properties. The aim of this research was to evaluate the biotransformations of bile acids (hyodeoxycholic acid, HA, and deoxycholic acid, DA), using microorganisms isolated from slaughtering houses of Ecuador. The biotransformations were analyzed by thin-layer chromatography (TLC) and nuclear magnetic resonance (NMR). The genus identification of the bacteria has been carried out by biochemical tests. The results showed that the more efficient bacteria for the biotransformation of HA were identified as Vibrio alginolyticus, Burk holderia pseudomallei, and Vibrio parahaemolyticus. For DA biotransformations, the most efficient bacteria were Proteus penneri, Burkholdeira pseudomallei, Pasteurella multocida, and Pseudomona aeruginosa. The low biotransformation capacity found in fungi may be due to the difference in metabolic pathways between the two types of microorganisms and that the best source for obtaining bacteria with biotransformation capacity (100%) of HA was the container of intestines, whereas for DA the best sampling area was the slaughtering area, isolating bacteria with a biotransformation capacity of 80%.

Idioma originalInglés
Título de la publicación alojadaCommunication, Smart Technologies and Innovation for Society - Proceedings of CITIS 2021
EditoresÁlvaro Rocha, Paulo Carlos López-López, Juan Pablo Salgado-Guerrero
EditorialSpringer Science and Business Media Deutschland GmbH
Páginas31-40
Número de páginas10
ISBN (versión impresa)9789811641251
DOI
EstadoPublicada - 2022
Evento7th International Conference on Science, Technology and Innovation for Society, CITIS 2021 - Virtual, Online
Duración: 26 may. 202128 may. 2021

Serie de la publicación

NombreSmart Innovation, Systems and Technologies
Volumen252
ISSN (versión impresa)2190-3018
ISSN (versión digital)2190-3026

Conferencia

Conferencia7th International Conference on Science, Technology and Innovation for Society, CITIS 2021
CiudadVirtual, Online
Período26/05/2128/05/21

Nota bibliográfica

Publisher Copyright:
© 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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