Biocatalytic approach for direct esterification of ibuprofen with sorbitol in biphasic media

Federico Zappaterra, Maria Elena Maldonado Rodriguez, Daniela Summa, Bruno Semeraro, Stefania Costa, Elena Tamburini

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

5 Citas (Scopus)

Resumen

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) introduced in the 1960s and widely used as an analgesic, anti-inflammatory, and antipyretic. In its acid form, the solubility of 21 mg/L greatly limits its bioavailability. Since the bioavailability of a drug product plays a critical role in the design of oral administration dosage, this study investigated the enzymatic esterification of ibuprofen as a strategy for hydrophilization. This work proposes an enzymatic strategy for the covalent attack of highly hydrophilic molecules using acidic functions of commercially available bioactive compounds. The poorly water-soluble drug ibuprofen was esterified in a hexane/water biphasic system by direct esterification with sorbitol using the cheap biocatalyst porcine pancreas lipase (PPL), which demonstrated itself to be a suitable enzyme for the effective production of the IBU-sorbitol ester. This work reports the optimization of the esterification reaction.

Idioma originalInglés
Número de artículo3066
Páginas (desde-hasta)1-18
Número de páginas18
PublicaciónInternational Journal of Molecular Sciences
Volumen22
N.º6
DOI
EstadoPublicada - 2 mar. 2021

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© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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