Actinomicetos con capacidad de biotransformación de sales sódicas de ácidos biliares

María Maldonado, Jessica Beltrán, Michelle Calvachi, Sebastián Espinel

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

1 Cita (Scopus)

Resumen

Bile acids are composed of 24 carbon atoms dihydric or trihydric, cholesterol derived. Ursodeoxycholic Acid, also known as chenodeoxycholic acid 7β-epimer, represents a small percentage of total bile acids naturally present in human bile, this is capable of increasing in humans the ability to solubilize cholesterol in bile transforming of lithogenic bile non-lithogenic bile (Roda, Roda, & Hofman, 1999). One major problem presented by the synthesis of ursodeoxycholic acid, is industrially generated contaminants. Deoxycholic hyodeoxycholic and obtained from the synthesis of ursodeoxycholic acid: Therefore in this investigation actinomycetes capacitymicroorganisms capable of steroid structures biotransformed as assessed. 21 strains of actinomycetes were isolated from soil samples of the City of Quito, Sevilla Don Bosco and Sucua. Biotransformation capacity isolates, salts of bile acids, object of the present study, using chromatographic and spectroscopic techniques were evaluated. Found that the most common reaction is the oxidation of the hydroxyl group at position 3 of the steroid structure.

Título traducido de la contribuciónActinomicets with biotransformation capacity of sodium sales of biliars acids
Idioma originalEspañol
Páginas (desde-hasta)150-158
Número de páginas9
PublicaciónRISTI - Revista Iberica de Sistemas e Tecnologias de Informacao
Volumen2020
N.ºE30
EstadoPublicada - jun. 2020

Palabras clave

  • Actinomycetes
  • Bile Acids
  • Biotransformation

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