In vivo Evaluation of the Antagonistic Effect of Lactobacillus acidophilus against Propionobacterium acnes in the Treatment of Acne

Tatiana De Los Angeles Mosquera Tayupanta, Victoria Sheila Pumisacho Ocana

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2 Scopus citations


Probiotics are able to inhibit certain pathogens, their use to fight acne caused by the proliferation of Propionibacterium acnes, would be an alternative in topical bacteriotherapy. There are studies of in vitro antagonism1. This study in vivo the antagonistic capacity of Lactobacillus acidophilus against Propionibacterium acnes in young people from 15 to 20 years old, with previous diagnosis of type II acne. First the evaluation of the in vitro antagonistic effect of Lactobacillus acidophilus against Propionibacterium acnes was performed. The measurement of the inhibition halos determined the concentration with antagonist effect 1x108 cfu/ml, with this concentration four formulations were tested, of these four only one had an in vitro effect; this formulation was subjected to a test of irritability (Mexican standard Nom-039-SSA1-1993) IPC = 0.19 defines the formula as “well tolerated”, the study of cosmetic activity in vivo was performed with a non-invasive method of exploration, using the Visiopor PP 34N® bioengineering instrument as a result, a 48-hour decrease in average porphyrins of 78.3% was obtained in the total number of treated individuals, which implies a decrease in the population of P. acnes, the acne-causing agent.

Original languageEnglish
Pages (from-to)1317-1324
Number of pages8
JournalJournal of Pure and Applied Microbiology
Issue number3
StatePublished - 1 Jan 2019

Bibliographical note

Funding Information:
The study was financed by Universidad Politecnica Salesiana and was the winner of the 2012 research call, in which the investigation was presented as a research topic of the Biotechnology Engineering career with the technical contribution of the Master of Science and Technology Cosmetics of the same institution.

Publisher Copyright:
© The Author(s) 2019. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.


  • Acne
  • Antagonist effect
  • Lactobacillus acidophilus
  • Propionibacterium acnes


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