Identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes

Andrés López-Cortés, Estefanía Abarca, Leonardo Silva, Erick Velastegui, Ariana León-Sosa, Germania Karolys, Francisco Cabrera, Andrés Caicedo

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Wound healing (WH) and cancer seem to share common cellular and molecular processes that could work in a tight balance to maintain tissue homeostasis or, when unregulated, drive tumor progression. The “Cancer Hallmarks” comprise crucial biological properties that mediate the advancement of the disease and affect patient prognosis. These hallmarks have been proposed to overlap with essential features of the WH process. However, common hallmarks and proteins actively participating in both processes have yet to be described. In this work we identify 21 WH proteins strongly linked with solid tumors by integrated TCGA Pan-Cancer and multi-omics analyses. These proteins were associated with eight of the ten described cancer hallmarks, especially avoiding immune destruction. These results show that WH and cancer's common proteins are involved in the microenvironment modification of solid tissues and immune system regulation. This set of proteins, between WH and cancer, could represent key targets for developing therapies.

Original languageEnglish
Article number17245
JournalScientific Reports
Volume11
Issue number1
DOIs
StatePublished - Dec 2021

Bibliographical note

Funding Information:
This work was supported by the Latin American Society of Pharmacogenomics and Personalized Medicine (SOLFAGEM). We thank the School of Medicine at the Universidad San Francisco de Quito, USFQ for their constant support of our work and initiatives. We are grateful to Vice-Rectorate for Research, the Directorate of the Life Sciences Area and the Biotechnology Career of Universidad Politécnica Salesiana for the support given in this investigation.We are thankful to the “Corporación Ecuatoriana para el Desarrollo de la Investigación y Académica, CEDIA” for the financial support provided to our project CEPRA XIV-2020-04, MITOCHONDRIAS, promoting the development of research and innovation in Ecuador.

Funding Information:
Publication of this article was funded by Universidad UTE, Universidad Politécnica Salesiana UPS, and Uni-versidad San Francisco de Quito USFQ by the project’s enregistrer in the HUBi database with the ID: 12468, 16925, 16999.

Publisher Copyright:
© 2021, The Author(s).

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