Determinación de la Capacidad Antioxidante de una Crema Elaborada con Extracto Isolado de Cannabidiol de Cannabis Sativa L. (CÁÑAMO)

The present investigation determined the antioxidant capacity of a facial antio-xidant cosmetic cream, made with Cannabidiol isolated extract. To establish the antioxidant capacity, the 2,2-Diphenyl-1-Picrylhydrazil method was used to apply a quantitative experimental design, ascorbic acid was used as a positive control. Antioxidant capacity of the extract and the cream formulated with the Cannabidiol extract were terminated. The concentration of the creams was va-ried with different Cannabidiol concentrations, ranging between 0.5 and 10%. The percentage of inhibition of the 2,2-Diphenyl-1-Picrylhydrazil radical of the Cannabidiol extract was 91.93% and for the cream it was 83.00% at the highest concentration of 333.33 μg/mL in both cases. Likewise, the IC50 values of the Cannabidiol extract and the cream were established with values of 62.60 μg ± 6.27 μg/mL and 77.93 ± 1.12 μg/mL respectively. The IC50 value of the extract is lower than that of the cream, which means a better antioxidant capacity of the isolated extract of Cannabidiol than that of the cream formulated with the extract.