Cardiovascular remodeling induced by intrauterine growth restriction manifests in adulthood by more globular ventricles, as evidenced by in vivo measurements. The angle between the dominant vectors of the QRS and T-wave loops has been reported to be significantly altered as a result of the induced remodeling. To investigate whether the more globular ventricular shape was a major factor contributing to such alteration, we performed electrophysiological simulations in a human biventricular model for control and in a model obtained by deforming the control one to represent a more spherical left ventricle (SLV). Transmural ventricular heterogeneities and a Purkinje network were included. 12-lead ECGs were calculated, from which spatial QRS and T-wave angles were computed. The angle between the T-wave and the XZ-plane was found to increase in the SLV model, showing a variation similar to that reported in in vivo studies. However, the angle between the dominant vectors of the QRS and T-wave loops projected onto the XY-plane was lower for control, contrary to clinical observations in IUGR adults. Other clinical results could not be reproduced in our simulations either. Our findings suggest that a more globular left ventricular shape leads to changes in the angles of QRS and T-wave loops, but further research is needed to fully understand these changes and the underlying mechanisms.
|Title of host publication||2020 Computing in Cardiology, CinC 2020|
|Publisher||IEEE Computer Society|
|State||Published - 13 Sep 2020|
|Event||2020 Computing in Cardiology, CinC 2020 - Rimini, Italy|
Duration: 13 Sep 2020 → 16 Sep 2020
|Name||Computing in Cardiology|
|Conference||2020 Computing in Cardiology, CinC 2020|
|Period||13/09/20 → 16/09/20|
Bibliographical noteFunding Information:
ship. This work was supported by projects ERC-StG 638284 (ERC), PID2019-105674RB-I00 and PID2019-104881RB-I00 (MICINN) and LMP124-18 and reference group T39-20R (Aragón Government cofunded by FEDER 2014-2020 ”Building Europe from Aragon”). Computations were performed using ICTS NANBIOSIS (HPC unit at U. Zaragoza). N. Ortigosa acknowledges support from Generalitat Valenciana under grant Prometeo/2017/102 and Spanish MINECO under grant MTM2016-76647-P.
I would like to acknowledge support by Fun-dación Carolina, Universidad de Zaragoza and Univer-sidad Politécnica Salesiana through its doctoral scholar- Figure 3. Vectorcardiogram 3D of depolarization loop (QRS) and repolarization (T) with its dominant vectors.
© 2020 Creative Commons; the authors hold their copyright.