Changes in QRS and T-wave Loops Subsequent to an Increase in Left Ventricle Globularity as in Intrauterine Growth Restriction: A Simulation Study

Freddy L. Bueno-Palomeque, Konstantinos A. Mountris, Ana Minchole, Nuria Ortigosa, Raquel Bailon, Esther Pueyo, Pablo Laguna

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

Cardiovascular remodeling induced by intrauterine growth restriction manifests in adulthood by more globular ventricles, as evidenced by in vivo measurements. The angle between the dominant vectors of the QRS and T-wave loops has been reported to be significantly altered as a result of the induced remodeling. To investigate whether the more globular ventricular shape was a major factor contributing to such alteration, we performed electrophysiological simulations in a human biventricular model for control and in a model obtained by deforming the control one to represent a more spherical left ventricle (SLV). Transmural ventricular heterogeneities and a Purkinje network were included. 12-lead ECGs were calculated, from which spatial QRS and T-wave angles were computed. The angle between the T-wave and the XZ-plane was found to increase in the SLV model, showing a variation similar to that reported in in vivo studies. However, the angle between the dominant vectors of the QRS and T-wave loops projected onto the XY-plane was lower for control, contrary to clinical observations in IUGR adults. Other clinical results could not be reproduced in our simulations either. Our findings suggest that a more globular left ventricular shape leads to changes in the angles of QRS and T-wave loops, but further research is needed to fully understand these changes and the underlying mechanisms.

Original languageEnglish
Title of host publication2020 Computing in Cardiology, CinC 2020
PublisherIEEE Computer Society
ISBN (Electronic)9781728173825
DOIs
StatePublished - 13 Sep 2020
Event2020 Computing in Cardiology, CinC 2020 - Rimini, Italy
Duration: 13 Sep 202016 Sep 2020

Publication series

NameComputing in Cardiology
Volume2020-September
ISSN (Print)2325-8861
ISSN (Electronic)2325-887X

Conference

Conference2020 Computing in Cardiology, CinC 2020
Country/TerritoryItaly
CityRimini
Period13/09/2016/09/20

Bibliographical note

Funding Information:
ship. This work was supported by projects ERC-StG 638284 (ERC), PID2019-105674RB-I00 and PID2019-104881RB-I00 (MICINN) and LMP124-18 and reference group T39-20R (Aragón Government cofunded by FEDER 2014-2020 ”Building Europe from Aragon”). Computations were performed using ICTS NANBIOSIS (HPC unit at U. Zaragoza). N. Ortigosa acknowledges support from Generalitat Valenciana under grant Prometeo/2017/102 and Spanish MINECO under grant MTM2016-76647-P.

Funding Information:
I would like to acknowledge support by Fun-dación Carolina, Universidad de Zaragoza and Univer-sidad Politécnica Salesiana through its doctoral scholar- Figure 3. Vectorcardiogram 3D of depolarization loop (QRS) and repolarization (T) with its dominant vectors.

Publisher Copyright:
© 2020 Creative Commons; the authors hold their copyright.

Fingerprint

Dive into the research topics of 'Changes in QRS and T-wave Loops Subsequent to an Increase in Left Ventricle Globularity as in Intrauterine Growth Restriction: A Simulation Study'. Together they form a unique fingerprint.

Cite this