This study was carried out to characterize chemical components by Gas chromatography-Mass spectrometry (GC-MS) of essential oils extracted from four endemic plants of Ecuador (Ocotea quixos, Clinopodium nubigenum, Piperomia inaequifolia and Psidium guayava) in order to evaluate its biological antifungal activities, against dermatomycosis causative dermatophytes fungi (Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis) and cutaneous candidiasis yeasts (Candida tropicalis, Candida albicans). It was tested the minimal inhibitory concentration (MIC) in vitro following disk diffusion method. Then the essential oils were incorporated in cosmetic formulations (creams) and efficacy evaluation were measure by statistical analysis and MIC. Cromatographic results revealed that essential oils from these plants possess interesting chemical-toxicological profiles: O. quixos (trans-cinnamaldehyde >25%), C. nubigenum (carvacrol acetate >40%), P. inaequifolia (myristicin >50%) and P. guayava (limonene >25%) as the majority compounds. The antifungal activities were expressed in a high inhibition capacity over the fungal growth, being O. quixos (bark) essential oil and formulations which showed the most significative biological activity compared to the natural referent T. vulgaris, fluconazole and nystatin as positive controls, denoting a promising medicinal potential. Keywords: Ocotea quixos, Clinopodium nubigenum, Piperomia inaequifolia, Psidium guayaba, GC-MS, dermatomycosis fungi, MIC, cosmetic formulation.
|Original language||English (US)|
|State||Published - Sep 2017|
|Event||The Scientific And Cultural Network XXVI - Cartagena de Indias, Cuba|
Duration: 25 Sep 2017 → 29 Sep 2017
|Conference||The Scientific And Cultural Network XXVI|
|City||Cartagena de Indias|
|Period||25/09/17 → 29/09/17|