General objective The objective of this project is to evaluate the antifungal activity of ethanolic extracts and essential oils from medicinal plants and to chemically analyze the secondary metabolites that give this activity to plants. Justification The incidence of mycotic infections, local and systemic, has increased in recent years, reaching alarming data. The phenomenon of fungal infections is closely linked to the physiologically developed resistance of the mycetes, which turn out to be immune to common therapies, to advances in medicine that allow the survival of severely ill and often immunocompromised patients, such as those subjected to steroid and oncological therapies, AIDS patients, etc. In the traditional medicine of all Latin American countries there are numerous plants with antibacterial and antifungal activity. As has been indicated, most antifungal drugs have severe adverse effects, they are also ineffective and frequently induce resistance, not to mention their high costs that make them inaccessible to the low-income population. Plants are an invaluable source of biologically effective molecules. They provide us with various secondary metabolites, many of which have antifungal activity. Among the best known compounds are: phenols, glycosides of phenols, saponins, terpene structures that make up essential oils.
|Effective start/end date||5/03/20 → 5/03/21|
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